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KMID : 1034720210130010007
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Journal of Neurosonology and Neuroimaging
2021 Volume.13 No. 1 p.7 ~ p.13
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High Erythrocyte Sedimentation Rate is Associated with White Matter Hyperintensity in a Healthy Population
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Nam Ki-Woong
Kwon Hyung-Min
Park Jin-Ho
Kwon Hyuk-Tae
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Abstract
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Background: High erythrocyte sedimentation rate (ESR) is related to various metabolic, cardiovascular, and cerebrovascular diseases; however, there is a limited study about its association with subclinical cerebral small vessel diseases (cSVDs). In this study, we evaluated the relationship between ESR and cSVDs in a healthy population.
Methods: We evaluated healthy check-up volunteers between 2006 and 2013. As subtypes of cSVD, we evaluated white matter hyperintensity (WMH), silent brain infarct (SBI), and cerebral microbleeds (CMBs). The WMH volume was rated quantitatively using a computer-assisted semi-automated technique. SBI and CMBs were evaluated qualitatively for presence.
Results: A total of 2,553 participants were evaluated. In multivariable linear regression analysis, ESR (β=0.027, 95% confidence interval [CI]=0.001 to 0.053, p=0.043) was significantly associated with WMH volumes after adjusting for confounders. Age (β=0.046, 95% CI=0.042 to 0.051, p<0.001), hypertension (β=0.187, 95% CI=0.092 to 0.281, p<0.001), and white blood cell counts (β=0.042, 95% CI=0.018 to 0.067, p=0.001) were also closely related to WMH volumes. ESR did not show any statistical significance with SBI or CMBs. In our data, ESR were closely related to age, sex, diabetes, hyperlipidemia, current smoking, systolic and diastolic blood pressure, and high-sensitivity C-reactive protein.
Conclusion: High ESR was associated with larger WMH volumes in a healthy population. Since this close association was not seen in SBI or CMBs, WMH may be more related to inflammation-related pathologies.
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KEYWORD
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Leukoaraiosis, Inflammation, Cerebral small vessel diseases, Erythrocytes
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